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Outpatient Management of Depression
4 - What to Say to the Depressed Patient and How to Say It |
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As part of the treatment planning, the clinician must decide
whether to treat the patient as an outpatient, in the hospital,
or refer to a psychiatrist. Hospitalization is generally based
on the following considerations: Is the patient at high risk
for suicide?
- Is the patient psychotic?
- Is the patient so functionally impaired that s/he cannot
ensure that basic needs will be met?
How to Assess the Suicide Risk
The prediction of suicide risk is imperfect at best, although
often obvious in hindsight. There are risk factors
that can be useful when assessing the patient's potential
for suicide (Table 4.1).
TABLE 4.1 — Risk Factors for
Suicide: “SAD PERSONS” Scale |
S — Sex: More
than three males for every one female kill themselves206
A — Age: Older > younger, especially Caucasian
males
D — Depression: A depressive episode precedes
suicide in up to 70% of cases
P — Previous attempt(s): Most people
who die from suicide do so on their first or second
attempt. Patients who make multiple (4+) attempts have
increased risk of future attempts rather than suicide
completion
E — Ethanol use: Recent onset of
ethanol or other sedative-hypnotic drug use increases
the risk and may be a form of self medication
R — Rational thinking loss:
Profound cognitive slowing, psychotic depression, pre-existing
brain damage, particularly frontal lobes
S — Social support deficit:
May be result of the illness which can cause social
withdrawal
O — Organized plan: Always need
to inquire about presence of a plan when treating a
depressed patient
N — No spouse: Again, may be a
result rather than a cause of the depressive disorder,
but nevertheless absence of a spouse or significant
other is a risk factor
S — Sickness: Intercurrent medical illnesses
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Previous suicide attempts bear special comment since they
are counterintuitive. Patients can be divided into those who
have a history of no or one previous suicide attempt and those
with multiple suicide attempts (more than 4 previous attempts).
The latter history is more suggestive of a personality disorder
rather than major depression. Such patients are more at risk
for future attempts than for suicide completion. While it
may initially seem counterintuitive, the absence of a history
of previous attempts does not substantially diminish the risk
of suicide completion. The reason is that the majority of
patients who commit suicide do so on their first or second
attempt. When the clinician is confronted with a moderate
to more severe, full depressive syndrome in a previously nonaffected,
middle-age-to-older patient, then suicide risk must be carefully
considered regardless of whether s/he has made a previous
attempt. This issue is particularly important in the patient
who has:
- A positive family history for suicide
- Prominent feelings of hopelessness and/or guilt.
How to Inquire About Suicidal Ideation
Some clinicians are uncomfortable about inquiring about suicidal
ideation. They believe that it will anger the patient. Others
believe that it may "plant the seed." A few may
not want to know the answer.
The first two concerns can be easily dispelled. Most patients
will be relieved and thankful that the clinician was sufficiently
concerned to inquire, assuming it is done in a tactful manner
as discussed below. There is also no evidence that such questioning
prompts patients to commit suicide. Instead, it uncovers patients
at risk so that appropriate preventive steps can be taken.
At the time the patient describes a depressive episode,
the clinician can empathize with the patient and simultaneously
begin exploring for the presence of suicidal ideation by saying:
"You sound as if you have been feeling pretty miserable.
Has life ever seemed not worth living?"
In response, most patients will spontaneously state they
have or have not had such thoughts. They often will go on
to say that they would never commit suicide for a variety
of reasons (eg, religious beliefs, effect on family and friends).
If the patient acknowledges feeling that s/he would be better
off dead, but does not explicitly state how actively s/he
has contemplated suicide, the clinician can follow-up by asking:
"So, you have felt that life was not worth living.
Have you ever thought about acting on those feelings?"
If the patient acknowledges that s/he has, the clinician
should then explore how far such thinking has gone:
- Does s/he have a plan?
- If so, what is it?
- Has s/he acted on it?
- If so, how recently?
If the patient has made a plan, has the means, or has recently
acted on it, then hospitalization is obviously needed. If
the patient is in a gray area, the clinician must decide how
impulsive the patient is and whether a good faith agreement
can be made to contact the clinician or come to a care facility
if suicidal ideation becomes intrusive, persistent, and compelling.
Is the Patient Psychotic?
A small percentage of patients with major depression in the
primary-care setting will have a mood-congruent hallucination
or delusion. Examples include: the patient hears a voice stating
that s/he is evil and deserves to die, or the patient believes
that s/he has contracted a serious illness as a punishment
for an earlier imaged sin or transgression. Such patients
warrant hospitalization because of the likelihood of acting
on the psychosis.
Is the Episode So Severe That Hospitalization
Is Necessary?
This issue requires the clinician to make several assessments:
- How much functional impairment has the depressive episode
caused?
- What are the functional demands on the patient at work
and at home?
- Are there support systems that can help offset any imbalance
between the patient's functional status and the functional
demands on the patient?
Based on the answers to the questions,
the clinician can determine whether the patient needs a release
from work and needs further functional support, up to and
including hospitalization.
Most patients with major depression seen in a primary-care
setting can be appropriately treated on an outpatient basis.
Nonetheless, the decision of where to treat and whether to
seek a consult or refer must be made with careful deliberation.
Initiating Outpatient Therapy
The first step is educational and empathic counseling. Patients
with any illness present with questions outlined in Table
4.2. Added to these universal questions are the following
issues commonly encountered in patients with major depression:
- They feel guilty or responsible for their illness
- In searching for a reason, they often attribute their
illness to outside factors such as "stresses"
on the job or at home
- Job or home-life problems may be a result rather than
a cause of their illness.
TABLE 4.2 — Patient’s Typical
Questions About Major Depression |
- What do I have?
- Will I feel better?
- What will it take to feel better?
- What should I do?
- What should I not do?
- Will it happen again?
- Do I need to be on medications indefinitely?
- Why did this happen to me?
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The clinician and staff need to address
these issues empathically and efficiently. That can be done
by anticipating common issues and providing standard educational
information without having to wait for the patient to ask.
The common questions/issues that patients have include:
You have major depression. Like many illnesses, we
do not completely know what causes it. We do know that it
runs in families like other illnesses such as diabetes and
hypertension. That fact and others lead us to believe that
major depression is due to biochemical changes in brain function,
sometimes described as a "chemical imbalance."
Although many patients who are depressed think they caused
it or that it is a sign of personal weakness, there is no
evidence to support this belief. It is no more true for major
depression than for diabetes or hypertension.
Yes. While we do not know precisely what causes major
depression, we do have a number of effective treatments for
it. With such treatment, you have an excellent chance of being
over this episode in a matter of weeks. Without such treatment,
you might get better spontaneously, but it could take months
or even years. Unfortunately, antidepressants do not work
for depressive episodes as aspirins do for headaches. It may
take 2 to 4 weeks of treatment before you start to notice
substantial improvement. Nonetheless, you will begin to
feel better.
You can think of response to antidepressants like the treatment
of a sore throat with antibiotics. While the antibiotic begins
to kill the bacteria within hours of starting it, there is
a period before you notice the improvement. In the case of
antibiotics, the delay is a couple of days. With antidepressants,
it may be a couple of weeks. Bear with it because you will
begin to feel better.
In the case of both antibiotics and antidepressants,
you should continue treatment for a period even after you
feel better. We generally advise you to keep taking an antibiotic
for 5 to 7 days after you feel better to ensure complete eradication
of the bacteria and thus reduce the likelihood of a recurrence
of the infection. We advise that you continue taking an antidepressant
for 4 to 5 more months after you feel better because that
is the interval during which you are at risk for a relapse.
We will discuss this issue further after you are feeling better.
The point now is to get you well.
- What Will It Take to Feel Better?
We use antidepressant medications to shorten the time
necessary to get over an episode. Most patients will experience
either significant improvement or a full remission from
their episode within a couple of weeks of starting an
antidepressant. In some individuals, full improvement can
take 6 to 8 weeks. Remember that these medications take time
to work and do not be discouraged by the fact that you do
not feel immediate relief. For you to respond, you need to
take the medication regularly as prescribed.
Some patients may worry that others might think that taking
antidepressant medication is a sign of "weakness."
People would never accuse a patient with diabetes of being
weak for taking insulin. You are feeling badly enough and
you should not be berating yourself for your illness. Instead,
let us work together to get you well.
Some patients wonder whether medications are the total answer.
They virtually never are for any significant illness, whether
it is major depression or hypertension. At a minimum, you
need to know about the illness so that you can optimally deal
with it.
Many patients with major depression will
respond fully to supportive counseling plus medications Others
may need more formal counseling called psychotherapy. Generally,
that decision is an individual one, between the clinician
and the patient.
There are several steps you can take to help in your treatment.
It is important to learn about your condition so that
you will know what to expect, particularly during the initial
period of treatment. Do not blame yourself for your
major depression. Realize that you did not ask to suffer from
it. Your self-esteem has likely been shaken as would be true
for anyone who has had such an episode. Give yourself a
reprieve from negative thinking for now. Take your medication
as prescribed. Get plenty of rest, stay physically active,
eat regularly, and keep socially involved.
Do not drink alcohol when suffering from major depression.
Alcohol causes similar changes in brain chemistry as occurs
during a depressive episode. Many patients with major depression
attempt to self-medicate by drinking alcohol to either help
themselves sleep or to "calm their nerves." Don't
do it. While it may initially help you to fall asleep, its
sedative effect wears off quickly causing early morning awakening.
For the same reason, do not use illicit drugs, or other sedative
agents or stimulants.
Do not make any major life decisions while moderately
or more severely depressed. What may seem like a mountain
of a problem when you are feeling poorly may seem much more
manageable when you are feeling better.
Although the focus now should be on getting
well, you may be concerned about the risk of future episodes.
The risk is primarily dependent on three factors: the duration
of the current episode, the number of previous episodes, and
your family history of major depression.
The likelihood of having recurrent episodes increases if
your first episode has lasted longer than 2 years, which is
one compelling reason to treat it aggressively now. Your risk
also increases with each subsequent episode (70% with one
previous episode, 90% with two previous episodes) and with
each first-degree relative (parents, siblings, offspring)
who suffers from major depression.61
The important thing is that major depression is highly
treatable. The vast majority of patients respond to antidepressant
medications. Most respond to the first agent used, but some
require treatment with a second antidepressant. Unfortunately,
we cannot "culture the bug" that causes major depression
like we can with a sore throat. If we could, we would be able
to select precisely the medication that would treat your depressive
episode the first time every time. Since we cannot do that
yet, we choose the medication that we think is most likely
to help you. If you do not respond to it, then we will use
a different type of antidepressant. Approximately, 60% of
patients will respond to the first medication.103
Of the 40% who do not, the majority will respond to the other
antidepressants, bringing the overall likelihood of response
to approximately 90%.
As you can see, major depression, if treated, has an
excellent prognosis and you should be feeling better soon.
- Do I Need to Be on Medications Indefinitely?
For the vast majority of patients, the
answer is no. For first-time episodes, we will treat
you for 4 to 5 months after you respond (total of 6 months
of therapy) and up to 12 months or longer for recurrent episodes.
After that period, we will taper and discontinue the medication.
(Note: Some researchers advise indefinite therapy if
the patient has had three previous episodes.)
We will educate you about the early signs of a recurrent
episode when we taper the medication. If you should have a
recurrence, this education can help you identify it early
and come back for treatment before the episode fully develops.
Some people with recurrent episodes may go years between
episodes so that prophylactic therapy with antidepressants
does not seem to be reasonable; instead each episode is treated
individually, much like recurrent episodes of a sore throat.
Although antidepressant medications have been used to prevent
recurrent episodes as well as to treat existing episodes,
the decision to stay on medication to prevent future episodes
is your decision. After all, you are the one who has to put
up with the cost of treatment and any adverse effects that
the medication may cause. Generally the decision to go on
maintenance therapy is made when the episodes become frequent
and/or severe. We do not need to make those decisions
now and will discuss it more after you have been well for
several months.
- Why Did This Happen to Me?
No one completely understands why some people suffer from
major depression, although it is clear that patients do
not cause or wish themselves to get ill. As we mentioned,
the condition runs in families, suggesting an inherited susceptibility.
We can think of clinical depression much like any other medical
illness such as diabetes or high blood pressure. Medication
plays a vital role in restoring normal body function. You
play an important role in your recovery by understanding your
condition to the best of your ability and by taking an
active and committed role in your recovery.
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